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Inani legciwane egazini eliphezulu

I-Delta ayidluliseleki kakhulu kunezinhlobonhlobo zangaphambili ze-SARS-CoV-2, futhi ingadala isifo esibi kakhulu. Abantu abangenwe ichweba elihlukile le-Delta cishe izikhathi eziyi-1,000 inani lezinhlayiya zegciwane (ochwepheshe abazibiza ngokuthi “igciwane lesandulela ngculazi”) ku-swab yabo yamakhala uma kuqhathaniswa nalabo abangenwe olunye uhlobo, “okuwukwanda okukhulu,” kusho u-Eric Topol, umsunguli kanye nomqondisi we-Scripps Research Translational Institute, owayengabandakanyekanga kulolu cwaningo.

Esinye isizathu salokhu ukuthi okuhlukile kwe-Delta kuphindaphinda ngokushesha ekhaleni. Ucwaningo, olungakabuyekezwa ontanga lubonise ukuthi okuhlukile kwe-Delta kuthathe isilinganiso sezinsuku ezine ukufinyelela emazingeni atholakalayo ngemva kokuchayeka kumuntu ogulayo, uma kuqhathaniswa nezinsuku ezingaba yisithupha zegciwane le-Wuhan.

Ngisho nangemva kokugoma, izifo ze-Delta zikhiqize inani legciwane egazini eliphindwe ka-10 kunezifo ezingezona eze-Delta. Eqinisweni ucwaningo oluningi lwakamuva, alukho untanga olubuyekeziwe okwamanje, lukhombisa ukuthi abantu abagonyiwe bathwala inani legciwane elifanayo njengalabo abangagonyiwe. "Sibona izifo futhi sibona isibalo esikhulu sabantu abangenwa yicala elilodwa, okukhathaza kakhulu. Kusho ukuthi leli gciwane lithathelwana kakhulu futhi liyakwazi ukugwema ... ukungatheleleki okubangelwa umgomo," kusho uRavindra Gupta, isazi se-microbiologist e-University of Cambridge, obehola ucwaningo olungakabuyekezwa kontanga.

I-Delta iphinde ibe ngcono ekucekeleni phansi amaseli ngenxa yoguquko endaweni engu-681 yephrotheni yayo eyi-spike, evame ukuvama ngokushesha kwezinye izinhlobo emhlabeni wonke futhi kucatshangwa ukuthi ishintsha umdlalo wokuziphendukela kwemvelo. Lokhu kuguqulwa kwe-P681R kwenza kube lula ukuthi i-Delta kanye nokuhluka okuhlobene kwe-Kappa kuhlasele iseli lomsingathi ngokuhlanganisa amaseli anegciwane abe yizakhiwo ezibizwa ngokuthi i-syncytium, okuyindlela yokusheshisa ukutheleleka. I-Syncytia nayo yenziwa ngamanye amagciwane afana ne-HIV. "Sithole ekuhlolweni kosikompilo lwamaseli ukuthi okuhlukile kwe-Delta kukhombisa i-syncytia enkulu uma iqhathaniswa ne-SARS-CoV-2," kuchaza u-Kei Sato, udokotela wezifo ezibangelwa amagciwane e-University of Tokyo, Japan.

Okuhlukile kwe-Delta kuphinde kwaba nezinguquko eziningi kuphrotheni yayo ye-spike ebonakala ithuthukisa ikhono legciwane lokubopha isamukeli se-ACE2 futhi ligweme ukuphendula kwamasosha omzimba.